human respiratory cell – Communicable Diseases Research

Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2

Research

Published on 2022-02-072022-10-05
Journal: Nature
[Category] COVID19(2023년), SARS, 신약개발, 치료제,

Furin cleavage of the SARS-CoV-2 spike is modulated by O -glycosylation

SARS-COV-2 스파이크의 푸린 절단은 O- 글리코 실화에 의해 조절된다.

407

Published on 2021-11-032022-08-13
Journal: Proceedings of the National Academy of Sciences of
[Category] Biochemistry, COVID-19, SARS,

[키워드] O- abrogate Alpha alpha and delta variants Amino acid amino acids cells circumvent cleavage coronavirus decrease delta variant Delta variants dependent on expressed family members furin furin cleavage furin cleavage of S furin cleavage site GALNT GALNT enzyme global pandemic glycosylating S glycosylation highlight host O -glycosylation host-mediated O -glycosylation human respiratory cell human respiratory cells increase insertion insertion site modulated modulating Mutation O -glycosylation P681 P681 mutation P681 mutations position position 681 proline pseudoviral infectivity respiratory responsible resulting SARS-CoV-2 coronavirus SARS-COV-2 infection shown Significance spike Spike protein syncytia formation target targets the SARS-CoV-2 the spike protein tropism unique Viral viral infectivity viral infectivity/tropism
[DOI] 10.1073/pnas.2109905118 PMC 바로가기 [Article Type] 407

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis

게놈 전반에 걸친 생물정보학 분석으로 SARS-CoV-2 발병의 주요 숙주 및 바이러스 요인 예측

Article

Published on 2021-05-172022-09-10
Journal: Communications Biology
[Category] SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus age analysis analyzed Betacoronavirus caused Computational biology and bioinformatics conserved contribute coronavirus COVID-19 CSF2 differentially expressed eIF4b eukaryotic Factor Genes help heterogeneous hnRNPA1 Host host gene expression host response host–pathogen interactions human gene human genes human respiratory cell human respiratory cells identify IL-6 IL32 Infection initiation factor interact Interaction isoform isoforms life cycle mechanism novel Betacoronavirus nuclear predict predicted Protein reduce respiratory respiratory cells ribonucleoprotein RNA SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 pathogenesis sequence sequencing data SERPINA3 severe acute respiratory syndrome Coronavirus severity of COVID-19 statistically significant the SARS-CoV-2 genome Therapeutics transcriptomics transposable element upregulated variant Viral viral genome sequence viral infection viral life cycle Viral RNA worldwide pandemic Wuhan Wuhan, China
[DOI] 10.1038/s42003-021-02095-0 PMC 바로가기 [Article Type] Article

SARS-CoV-2 variants reveal features critical for replication in primary human cells

SARS-CoV-2 변이체는 1차 인간 세포에서 복제에 중요한 기능을 나타냅니다

Research Article

Published on 2021-03-242022-08-13
Journal: PLoS Biology
[Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome coronavirus BEpCs bronchial epithelial cell causative agent change characterization characterized circulation clade contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 pandemic Critical D614G variant deaths Deletion determine effort epithelial cells European exhibited experiments expressing feature furin furin cleavage site Genetic variant highlight human population human respiratory cell human SARS-CoV-2 Infection isolate kinetic MONITOR NSP2 ORF3a pandemic Patient Phenotypes primary differentiated human bronchial epithelial cells primary human cell primary human cells primary human respiratory cells Q57H Replication representing respiratory SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants selected sequence Sequencing sequencing data severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike D614G variant Spread Substitution substitutions T85I the Spike Transmission variant variants of concern Vero-CCL81 Vero-CCL81 cell Vero-CCL81 cells Viral virus virus replication virus stocks while
[DOI] 10.1371/journal.pbio.3001006 PMC 바로가기 [Article Type] Research Article